Persistent Restricted Diffusion Abnormalities in Bevacizumab-Treated Glioma Patients: Relationship to Outcomesχ

Keywords

abnormalities abnormality abscess absence activity acute advanced aggressive alone analyzed applied atypical barrier biopsy blood brain chemotherapies chronic clinical coefficient cohort comparing computed confirmed consent consistent content controls correlate correlation criteria curves days debated decreased decreases decreasing define described developed development diagnosis diffusion either emerging endothelial enhancement enhancing fact faintly findings free grade grades granted greater growing hemorrhage histology history hypothesis hypoxia included inclusion increasing induced initial initiation institutional intracellular irradiation least lesion lesions localize longer matched measures median membranes models months near necrosis noted observations occurred occurs onset outcomes overall pathology patients persisted persistent persistently pope positive predicted presence previous progression proxy radiology rank rather recurrent reduces reflecting relationship representative resection respectively response rest restricted restriction review score selected setting significance significantly similarly site spatially specimens spectrum stable student studies subsequent suggests support surgical survival sustained targeted temporal therapeutic though towards treated treatment trended tumor unpaired uptake vascular versus volume