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Abstract #0827

Decreased Creatine in NAWM Suggest a Reduced Gliosis in Natalizumab Treated MS Patients

Anders Tisell1, 2, Johan Mellergrd3, 4, Olof Dahlqvist Leinhard1, 2, Charlotte Dahle5, Jan Ernerudh6, Magnus Vrethem7, Anne Marie Landtblom3, 4, Peter Lundberg, 28

1Division of Radiological Sciences, Department of Medicine and Health Sciences, Linkping University, Linkping, Sweden; 2Center for Medical Image Science and Visualization (CMIV), Linkping University, Linkping, Sweden; 3Neurology, Department of Clinical and Experimental Medicine, Division of Neuroscience, Linkping University, Linkping, Sweden; 4Neurology Clinic, UHL, County Council of stergtland, Linkping, Sweden; 5Clinical Immunology, Department of Clinical and Experimental Medicine, Linkping University, Linkping; 6Clinical Immunology, Department of Clinical and Experimental Medicine, Linkping University, Linkping, Sweden; 7Neurology and Clinical Neurophsiology, Department of Clincal and Experimental Medicine, Linkping University, Linkping, Sweden; 8Depts of Radiation Physics, Linkping University and Radiation Physics, UHL, County Council of stergtland, Linkping, Sweden

Absolute quantitative magnetic resonance spectroscopy was used for assessing the effects of natalizumab treatment on the metabolism in normal appearing white matter of MS patients. A significant change in creatine concentrations during extended treatment (three years) was observed. As creatine is more abundant in glia cells than in neurons this change suggests a reduction of glia concentration. Although higher concentrations of myo-inositol, choline containing compounds and total glutamine+glutamate were observed in the patients compered to healthy controls, the concentrations did not change in the patients as a consequence of the therapy.

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Keywords

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