Meeting Banner
Abstract #0823

Multi-Modal Post Mortem MRI at 7T to Detect and Quantify Multiple Sclerosis Cortical Grey Matter Pathology

Olivier E. Mougin1, Niraj Mistry2, Penny A. Gowland1, Nikos Evangelou2, Klaus Schmierer3

1Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, Select, United Kingdom; 2Institute of Neuroscience, Nottingham, Select, United Kingdom; 3Barts and The London School of Medicine & Dentistry, Blizard Institute, Centre for Neuroscience & Trauma (Neuroimmunology Group), London, United Kingdom

To explore their potential to detect cortical grey matter pathology we acquired T2 weighted (T2w), T2*w, double inversion recovery, phase-sensitive inversion recovery, and magnetization transfer ratio using fixed post mortem MS brain. Voxels of 0.35mm isotropic gave a clear delineation of the grey matter, both non-lesional and lesional. Our results suggest T2w and T2*w MRI are currently the best techniques to detect cortical grey matter lesions in post mortem MS brain.

Keywords

able adjacent allow amount amplitude apparent applied assessment bandwidth bath best better bibliography body brain channel characteristics chosen classified coarser coil compartments comprehensive confidence confirmation confirming contrast control correlates cortical death delineation depiction detect detectable detected detection disease divided double drawn earlier easily either enabling enhance equipped explore female field findings five fixation fixed fluid formalin gradient head hemisphere highest holder hours immersed important in vivo inability include independent independently insert institute interface intra inversion investigated investigating isotropic kingdom lack lesion lesions limited magnetization manually maps medical mixed modalities modality need nelson nervous neurology noise nova occurring onto optimize optimized pathological pathology penny peter placed post promises properties pulses purely quadrature quantification quantify quantitative radiology receiver recent recovery registered registration researchers resolution sample saturation scanner scanning school sclerosis select sensitive separate slice spectra spinal structure studies successfully summarized susceptibility system systems taken tissue together transfer transmit trauma types visible volume volumes white whole