Histological Basis of Diffusely Abnormal White Matter in Multiple Sclerosis: Evidence for a Primary Lipid Abnormality

Keywords

abnormal abnormalities abnormality acid acidic anisotropy antedates appearance arch arrows axon axons background basis blue boundary brain characteristically clinical coil consistent content contribute cyclic decreased decreases define defined degeneration density determined difficult diffusely disability disease dramatic duration either elucidate embedded error examined expressed extensively families fast features field findings fixed formalin fourteen fraction fractional free funding giving head histological histology importance important included indicating individuals intermediate interquartile involvement known laboratory least lesion lesions lipid lipids little makes mapped markers matrix measures medicine minutes negative network nucleotide optical outliers outlined paraffin particular pathology people perturbation phenomena plus poorly potential preserved previous primary prognostic progress progression prominent protein proteins proton quantitative radiology reduced reductions reflecting registered related relatively reported residues resolution respectively rise sample sclerosis short shorter slices squares stained staining stains statistical studies subjects substantial suggesting summarized support table thick tissue training transfer trials typically underlying view warranted water white wise women