Meeting Banner
Abstract #0816

Limbic Scars: Functional and Structural MRI Reveal Long-Term Consequences of Childhood Maltreatment

Harald Kugel1, Anja Stuhrmann2, Victoria Beutelmann2, Peter Zwanzger2, Thomas Lenzen2, Dominik Grotegerd2, Katharina Domschke2, Christa Hohoff2, Patricia Ohrmann2, Jochen Bauer2, Christian Lindner2, Christian Postert2, 3, Carsten Konrad4, Walter Heindel1, Volker Arolt2, Thomas Suslow5, Udo Dannlowski2

1Department of Clinical Radiology, University of Muenster, Muenster, NRW, Germany; 2Department of Psychiatry, University of Muenster, Muenster, NRW, Germany; 3Department of Child and Adolescent Psychiatry, University of Muenster, Muenster, NRW, Germany; 4Department of Psychiatry, University of Marburg, Marburg, HE, Germany; 5Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig, Leipzig, SN, Germany

Childhood maltreatment is a strong risk factor for the development of depression and posttraumatic stress disorder (PTSD) in later live. In this study, the neurobiological bases of these associations were investigated. Both, depression and PTSD have been associated with increased amygdala responsiveness to negative stimuli as well as reduced hippocampal gray matter volume, therefore we speculated that childhood maltreatment results in similar functional and structural alterations in previously maltreated but at present healthy adults. fMRI and voxel-based morphometry were applied to investigate the alterations.

Abstract PDF Poster PDF

Keywords

accuracy activate activation addition adolescent adrenal adulthood adversities alterations analyzed anterior anxiety artifacts assessed association associations axis behavioral blocks bottom brain causes child childhood clinical cluster coefficient color consequences consulting contrast control coronal corr corrected correlation cortex created cubic decades depicting depression described determined development direct disorder disorders drop edge education emotional enrolled even events every experiences expressions faces facial fast fear fearful findings functional geometric gilbert gradient gray healthy hyper identical influenced interval lancet lasting length limbic long maltreated maltreatment mask measured mediators might minimize modulated muenster negative normalized panel paradigm particularly pictures pituitary positive positively previously projected psych psychiatric psychiatry psychosomatic psychotherapy questionnaire radiology reaction rear recent recorded reduced related resolution response responsiveness restricted reveal risk scanner scars science scores screen select shapes shin shot space stimuli stress stressful strong strongly structural studies subjects suggest supplementary task term threat threshold toolboxes trait trauma trio trios uncorrected view volumes whole