Meeting Banner
Abstract #0800

Volumetric Pseudo-Continuous Arterial Spin Label (PCASL) Imaging in Chronic Alcoholism: Return to Default Mode Network Activity Levels After a Spatial Working Memory Task

Edith V. Sullivan1, Eva M. Mller-Oehring1, 2, Anne-Lise Pitel1, Sandra Chanraud1, Ajit Shankaranarayanan3, David C. Alsop4, 5, Torsten Rohlfing2, Adolf Pfefferbaum, 12

1Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States; 2Neuroscience Program, SRI International, Menlo Park, CA, United States; 3GE Healthcare, Menlo Park, CA, United States; 4Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States; 5Radiology, Harvard Medical School, Boston, MA, United States

3D whole-brain pseudo-continuous arterial spin labeling (PCASL) measured cerebral blood perfusion (CBF) in alcoholics and controls while resting, task-engaged, and resting again. Based on bilateral, normalized CBF, both groups showed a default mode network (DMN) pattern (high activation for rest, low for task, return to high CBF in second rest) in medial frontal, temporal, calcarine, insular, cingulate, posterior precuneus cortices and hippocampus-amygdala, and a task-activated pattern (high task activation, low for rest) in cerebellum, parietal, occipital, middle precuneus cortices. Alcoholics differed from controls in CBF levels of insula and the rest-task-rest CBF pattern for anterior precuneus, regions involved in addiction.

Abstract PDF

Keywords

account accuracy achieved activated activation activations activity adults alcohol alcoholic alcoholics alcoholism aligned analyses anatomical anterior arterial asked atlas back beth bias bilateral black blood brain campus cerebellum chronic circuitry comprised concepts condition conditions consent continuous controls corrected cortex cortices dark date days default dependents despite disease displays disturbance dividing drank drinking dual early education employed ever exhibited express eyes fast flow frontal functioning gave generated global gray handedness incidence included indicated influence insular interaction label late lateral least light local location mask masks match matrix matte medial medical medicine memory middle mode modify native natl network networks neural none nonrigid normalized occurring opposite oral parietal park participation past pattern patterns pends performance perfusion permitted posterior previously probability proceedings pseudo quantification radiology recovering refrain regional related rest return revealed runs sciences selective skip skull space spatial spin stripped stripping subject superior task tempo thick tissue volumetric voting white whole written years