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Abstract #0784

BOLD Imaging of Adults & Infants Under Hypoxia and Hyperoxia

Matthew Borzage1, 2, Bimal Agrawal1, John Wood, 23, Ashok Panigrahy4, 5, Marvin D. Nelson4, Istvan Seri1, 6, Stefan Blml4, 7

1The Center for Fetal and Neonatal Medicine and the USC Division of Neonatal Medicine, Children's Hospital Los Angeles, Los Angeles, Ca, United States; 2Viterbi School of Engineering, University of Southern California, Los Angeles, Ca, United States; 3Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, Ca, United States; 4Radiology, Children's Hospital Los Angeles, Los Angeles, Ca, United States; 5Pediatric Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pa, United States; 6Keck School of Medicine, University of Southern California, Los Angeles, Ca, United States; 7Rudi Schulte Research Institute, Santa Barbara, Ca, United States

Blood oxygenation level dependent signal changes due to hypoxia and hyperoxia in healthy adults and a neonate were acquired. Exponential curves were fitted to parameterize the rate of change following FiO2 manipulations and the rates of change were compared. The rate of recovery from hypoxia depended on the subject scanned: adult recovery was markedly more rapid than the neonatal recovery. This preliminary data indicates that there may be substantial differences between the neonatal brain and adult brain when reacting to oxygen manipulations.

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