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Abstract #0769

Resting State Functional Connectivity Abnormalities Are Associated with Cognitive Impairment in Patients with Pediatric Multiple Sclerosis

Maria A. Rocca1, Paola Valsasina, Maria Pia Amato2, Martina Absinta, Angelo Ghezzi3, Lucia Moiola4, Agnese Fiorino4, Pierangelo Veggiotti5, Andrea Falini6, Giancarlo Comi4, Massimo Filippi, the MS and Neuroimaging Study Groups of the Italian Neurological Society7

1Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy, Italy; 2Department of Neurology, University of Florence; 3MS Centre, Ospedale di Gallarate; 4Department of Neurology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy; 5Department of Child Neurology and Psychiatry, Fondazione IRCCS Istituto Neurologico C Mondino, Pavia, Italy; 6Department of Neuroradiology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy; 7.....

In this study, we assessed functional connectivity (FC) at resting state (RS) within and among cognitive networks in 34 patients with pediatric multiple sclerosis (MS) and 18 age- and sex-matched healthy controls. Decreased FC was found in regions of the posterior lobes, as well as in the cerebellum of the attention network, salience network (SN) and executive control network (ECN). Conversely, increased FC was found in frontal regions of the SN and of the default mode network (DMN). A decreased FC was associated with cognitive impairment, whereas increased FC was correlated with a lower structural damage.

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Keywords

abnormalities active among assess assessed attention brain cerebellum child cognitive cognitively component confirming connectivity control controls conversely coordinates corrected correlation correlations cortex damage decrease decreased default details detected disconnected dual error executive experimental explore explored expressed family focal frontal functional grant health healthy identify impaired impairment independent inferior institute interaction interactions legend lesion lesions lobes maria matched matching ministry minor mode model network networks neurological neurology never objective occipital occur partially patients patterns pediatric positive posterior preserved previous procedure psychiatry related reserve respectively resting salience salute scientific sclerosis score seems significantly society space spatial structural studies subjects superior supported table template thresholded toolbox unit vita volume whereas wise