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Abstract #0763

New Insights of Carotid High-Risk Atherosclerotic Plaques Determined by Proportion of the Arterial Wall Occupied by the Lipid-Rich Necrotic Core in Symptomatic Patients: A 3.0T MRI Study

Xihai Zhao1, Huilin Zhao2, Jinnan Wang3, Feiyu Li4, Jie Sun5, Jianrong Xu2, Chun Yuan, 15

1Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China; 2Department of Radiology, Shanghai Jiao Tong University Renji Hospital, Shanghai, China; 33. Philips Research North America, Briarcliff Manor, NY, United States; 4Department of Radiology, Peking University First Hospital, Beijing, China; 5Department of Radiology, University of Washington, Seattle, WA, United States

Neurological symptoms caused by advanced carotid atherosclerosis with intraplaque hemorrhage (IPH) or fibrous cap rupture (FCR) may exist as these lesions detection. As such, investigation of carotid lesions before advanced stage might be helpful for stroke prevention. Recently, Underhill et al proposed carotid atherosclerosis score (CAS) that effectively stratifies plaques risk of developing future IPH/ FCR. This study investigated the incidence of high-risk lesions determined by CAS in symptomatic patients. We found a substantial number of lesions with higher CAS value exist in carotid arteries with low grade stenosis, suggesting the necessity of direct characterizing LRNCs using black-blood MRI techniques.

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Keywords

absence according acquisition addition administration advanced array arterial arteries artery atherosclerosis axial best bifurcation biomedical black blinded blood body boundaries calcification calculation captured cardiovascular carotid cascade categories caused channel characterization china circulation clinical coil common compositional consensus core custom designed desirable detected determined develop developed developing direct disease double early effectively engineering events exhibited exist features field fifteen findings future grade heart hemorrhage hospital incidence index insights investigate investigated investigation lesion lesions lipid location lumen males manor matrix measured medical medicine medium might necessity necrotic neurological neurosurgery north occupied occurrence outer particularly patients people plaque plaques potentially presence prevalence prevention previously prior progressing proportion proposed published radiology rage recent recently reconstructed recovery recruited reduction regressed represents republic respectively responsible reviewers rich risk rupture scanner school score shanghai slice software solution sought stratifies stroke subjects substantial suggest symptomatic symptoms system table tong traced treat trials triggering view wall week whole years yellow