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Abstract #0735

Towards Building a High Resolution Atlas of Mn2+ Deposition in Rat Brain

Dai Shan1, Shaorui Li1, Liqin Yang2, Hao Lei1

1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, China; 2Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, China

In this study we proposed a protocol to analyze high resolution MEMRI data with a voxel-based approach. The aim is to build a high resolution MEMRI atlas which can be used to reveal fine cytoarchitecture of the brain at the group level, and to identify functionally distinct brain regions which show differential activities in Mn2+ uptake/deposition

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Keywords

academy access accuracy activation activities administration afferent affine amount anesthesia animal animals array artifacts atlas atomic axis barrier blue brain build building changing channel china coil cold color consecutive coordinate corrected cortical created daily dataset datasets days delineated denotes deposition detected detection diameter differential distinct distributes efferent enhanced external fine flash food foundation functional functionally generation gray identify independent individual initial injection institute intensity internal isotropic journal kernel laboratory laminar lateral layer light local male manganese manually many mapping materials mathematics matrix medial ministry mixed molecular nearly neuronal normalized nuclei nucleus olfactory part particular pattern people permeability physics pixel pixels posterior preparation procedures profiles projections proposed protocol pyramidal rats regional registered registration representative republic resolution respectively reveal revealed samples scanner science sciences shed spatially statistical statistically stripped structure structures subjected supported systemic tailed template templates tissue towards tract transformation transmission treatment twelve uncorrected uptake volume warm white whole widely wise yang