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Abstract #0689

SIFT: Spherical-Deconvolution Informed Filtering of Tractograms

SUMMA25Robert Elton Smith1, 2, Jacques-Donald Tournier1, 2, Fernando Calamante1, 2, Alan Connelly1, 2

1Brain Research Institute, Florey Neuroscience Institutes, Heidelberg, Victoria, Australia; 2Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia

When performing whole-brain fibre-tracking using Diffusion-Weighted Imaging, certain pathways in the brain can be over- or under-estimated, due to the independence of individual streamlines, and any methodological biases of the models or algorithms used. To improve the biological accuracy of connectome reconstruction, we propose a normalisation process for whole-brain fibre-tracking data, which uses the results from spherical deconvolution to selectively filter tracks from the data set, matching the track densities in high angular resolution space to the estimated intra-cellular volume fractions.

Keywords

account accuracy accurate achieve addition aligned alignment amplitude amplitudes analyses anatomical angular better biases biology brain bundles capability completed compression computed connections connectivity construct contribution coronal correspond cost coverage deconvolution decrease defined densities density described desktop diffusion distributions entire exceeding expense explicit fact fewer filtering fold folds fraction function generated gradient healthy hence homogeneity homogeneous human improving in vivo independently individual inferior influence initial institutes integration intra introduced isotropic just length local many measures methodological million models much numerical orientation orientations overall package part particular pathways peak peaks perfect pons post predominantly press probabilistic process processing produced proton providing reconstruction reduced reduction regarding rely remain removal removed repeated require resolution respect retention rigid running scalable scales seeding segmentation sift significantly simple simulation slices smith software space spherical start still strategies streamlines structural superior thereof throughout tissue tissues toward track tracking tracks traversed traversing trio underlying unfortunately upon vector volume white whole whose yield