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Abstract #0664

Noninvasive Estimation of Pulmonary Vascular Resistance with 4D Flow-Sensitive MRI in a Canine Model of Acute Pulmonary Arterial Hypertension

SUMMA25Alejandro Roldan-Alzate1, Alex Frydrychowicz2, Leif Jensen1, Scott K. Nagle1, Heidi Kellihan3, Naomi Chesler4, Oliver Wieben1, 5, Christopher J. Franois1

1Radiology, University of Wisconsin, Madison, WI, United States; 2Radiology, Universitatsklinikum Schleswig-Holstein, Lubeck, Germany; 3Veterinary Medicine, University of Wisconsin, Madison, WI, United States; 4Biomedical Engineering, University of Wisconsin, Madison, WI, United States; 5Medical Physics, University of Wisconsin, Madison, WI, United States

Pulmonary vascular resistance (PVR) is a hemodynamic parameter that is used to assess disease severity and to guide the management of patients with a variety of cardiovascular and pulmonary conditions. 4D flow-sensitive MRI is increasingly being used for hemodynamic analyses of cardiovascular diseases, including pulmonary arterial hypertension. PC VIPR is a time-efficient 4D flow-sensitive MRI technique, using radial undersampling, to obtain high spatial resolution data with a large volume of coverage. In this study we validated the use of PC VIPR data for the estimation of PVR in a canine model of acute pulmonary arterial hypertension.

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Keywords

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