Meeting Banner
Abstract #0658

Deep Brain Stimulation fMRI of the Rat Ventral Posterior Medial Thalamus

SUMMA25Yen-Yu Ian Shih1, Yash Vardhan Tiwari1, William E. Rogers1, Timothy Q. Duong1

1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

This study demonstrates thalamocortical connectivity by direct stimulating the ventral posterior medial thalamus in rats. Our results indicate that the barrel cortex is reliably activated and the BOLD responses exhibit frequency and amplitude-dependent properties. Cortical spreading depolarization occasionally occurred, initiating in the barrel cortex and propagating toward the midline, anterior, and posterior part of the cortex within the same hemisphere. DBS-fMRI has potential to explore/validate functional connectivity in the brain and monitor functional plasticity changes in a specific neuroanatomical pathway in vivo.

Abstract PDF Presentation Video

Keywords

able activation adjusted adult affected aimed amount amplitude anatomy anesthetized animals anterior assist atlas bands barre barrel bars bipolar bold brain calibrating cement certain coil combining comp connectivity contrast coordinates cortex cortical course deep delivered dental dependent depth differed discuss disease dynamics edition elected electric employed epoch error evoke evoked exhibit experiment explore field finding firs fixed frequencies frequency gradient grand health heated hemisphere highlights hods hypothesis indicates induce induced initiate initiated intro largely larger lateral lesion lesioned located long major matrix mechanism medial monitor monitoring nervous neurological neurons never occurred onset optical optima optimal outcome overlaid pared part peak peaked post posterior produced propagated pulse rats reached reliable remain repeated reproducible resolved respiratory response responses rogers science sensory shaded shape shot slice spreading square still stimulation stimuli stimulus stroke stud surface temp temporal thalamus third tidal trials unambiguously unknown validate variety various varying ventilated wave ween whole width widths window