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Abstract #0631

Noninvasive In-Vivo Quantification of Compensatory Lung Growth Following Pneumonectomy, Via 1H & 3He MRI

SUMMA25Wei Wang1, 2, Nguyet M. Nguyen3, Jinbang Guo1, Yulin Chang2, Dmitriy A. Yablonskiy2, Richard A. Pierce3, Jason C. Woods, 12

1Physics, Washington University in St. Louis, St. Louis, MO, United States; 2Radiology, Washington University in St. Louis, St. Louis, MO, United States; 3Internal Medicine, Washington University in St. Louis

Pneumonectomy (PNX) is a robust, established model of compensatory lung growth. Understanding the time course and the mechanism of compensatory lung growth will promote understanding of post-natal lung growth and regeneration. 3He lung morphometry has been successfully implemented in humans for years, and was recently developed and validated in mice. Here we image in-vivo morphometry at baseline and serially assess compensatory growth after PNX in mice via 1H and 3He MRI. The results demonstrate that in addition to growth of alveolar size, the total lung volume, alveolar number and lung compliance are restored to baseline levels by compensatory lung growth.

Keywords

accessory acquisition adult airway airways alveolar alveoli animal animals approval arrow assess assessment axial basis become beginning blood breath breaths brief calculating characterization clear coil compatible compensatory complete compliance consisted consistent control counting course coverage cycle days decreased determined diffusion dogs embedded employed enabled enlargement exhalation expansion extending field fitted five fold gain gradient great growth histology hold horizontal humans immediately in vivo individual inhalation inhaled initial insight linear lobe lobes longitudinally lung lungs magnet many maps matrix mechanical mechanism mice minute mixture model mouse multiplying natal nearly noninvasive normalized operation overall parametric part peak period physics physiological post pressure prior properties quantification quantitative rats recently regeneration regional remained remaining removal reported representative resection residual resonant respectively respiratory restored serially sham shed sided significantly slice slices software solenoid static strength studies subjected suggesting supine surface surgery thorax tissue tomographic tool tuned unchanged understanding underwent validated valuable variation ventilated ventilator vessels view volume woods