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Abstract #0580

Implementation & Validation of Time Encoded Pseudo Continuous Arterial Spin Labelling for Human Applications.

MAGNA25Wouter M. Teeuwisse1, Ilya M. Veer, Andrew Webb1, Matthias J.P. van Osch1

1C.J.Gorter Center for High Field Magnetic Resonance, Radiology, Leiden University Medical Center, Leiden, ZH, Netherlands

In this study, time encoded pCASL is implemented on a clinical 3T scanner. Following a Hadamard encoding scheme, pCASL is modified such that the labelling period is split into blocks with varying label/control condition. This enables calculation of perfusion maps with 11 different post labelling delays from a single scan. Two versions were evaluated, one with blocks of constant duration and one with block duration adjusted for T1 decay of labelling signal. Resulting, whole brain, perfusion maps clearly show local and global variation in arterial filling and tissue enhancement over time. Quantitative ATT maps demonstrate the flow territory border zones.

Keywords

achieve acquisition acquisitions adequate adjusted already although animals applied appropriate approx arterial background basal better block blocks blue bolus border bottom cerebral challenging chosen clearly clinical columns comprising condition consecutive consistent continuous control convolution corrected decay delay delays demonstrating derivative deviation discerned disease dispersion divided dividing duration effective efficient eight enables encoded encoding enhancement equal estimation evaluation except expense extract extracted female field fixed flow function ganglia gauss global healthy highly human humans identical implement implementation improved indicate inflow label labeled labeling local made manner maps mask measured medical module motion noisy oxford patients patterns performance perfusion period post posterior processing proposed protocol prove pseudo quantitative quasar radiology recently reducing registered rendering representative resolution sampling scanned scanning scheme selecting served sets shot significantly slices slightly spin spins subject subjects subsequent suffers summed suppression system temporal territory tissue tool train transit typical validation variation vary veer vessel vessels volunteer wider wise zones