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Abstract #0503

Brain Sodium Accumulation & Spreading Correlate with Disability in Multiple Sclerosis

Wafaa Zaaraoui1, Simon Konstandin2, Bertrand Audoin1, Armin M. Nagel3, Audrey Rico1, Irina Malikova1, Elisabeth Soulier1, Patrick Viout1, Sylviane Confort-Gouny1, Patrick J. Cozzone1, Jean Pelletier1, Lothar R. Schad2, Jean-Philippe Ranjeva1

1CRMBM UMR CNRS 6612 - Aix-Marseille Universit, Marseille, France; 2Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany; 3German Cancer Research Center (DKFZ), Department of Medical Physics in Radiology, Heidelberg, Germany

The key role of sodium accumulation leading to neuronal injury in multiple sclerosis has recently been highlighted. Using in vivo sodium MRI at 3T, we have characterized for the first time the spatial spreading of brain sodium accumulation in two groups of relapsing remitting multiple sclerosis (RRMS) patients (13 early RRMS and 13 advanced RRMS) compared to 15 healthy controls. Brain sodium accumulation was present from the early stage of RRMS and dramatically spread during the course of the disease in the whole brain especially in the normal appearing tissues concomitantly to progression of disability and independently from atrophy.

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Keywords

abnormal abnormalities accumulation accumulations acquisition adapted advanced aimed appearing appears application assisted atrophy bilaterally biomedical brain cancer cascade cerebellum characterize circumscribed clinical close coil compartment compartments computer concentrations concomitantly controls corpus correlate correlated cortices course delineation density developed dimensional disability disease dramatically duration early element entire especially explorations external field filtering finally frontal functional global head healthy highlighted holding home illustrated in vivo included independently inflammation injury inside jean kernel leading lesion lesions load lobes locate made mapping maps mask masks matrix medial medical middle motor neuronal nominal normalization nuclear objective occipital occurring onto optimized options pathological patient patients physics pipeline placed planning post primary procedure processing progression projection projections proton pulse quantify quantitative radial radiology rank rapid recently reconstruction relapsing relevant remitting resolution resolved role samples sclerosis serve slices smoothing sodium spatial spreading spreads stages statistical steps stressing subject subjects superior system temporal thalami tissues tool tubes view volume white whole widespread