Meeting Banner
Abstract #0475

Comparable Spatio-Temporal Characteristics But Differences in Metabolism-CBF Coupling in Intrinsic Connectivity Networks Identified from Simultaneous BOLD & CBF

SUMMA25Stephen D. Mayhew1, Karen J. Mullinger2, Andrew P. Bagshaw1, Richard Bowtell2, Susan T. Francis2

1Birmingham University Imaging Centre, School of Psychology, University of Birmingham, Birmingham, West Mids, United Kingdom; 2SPMMRC, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom

Highly correlated, spontaneous fluctuations in fMRI signals define functionally relevant intrinsic connectivity networks (ICNs). BOLD and ASL data were simultaneously acquired during median nerve stimulation. Group ICA was performed on both BOLD and ASL data sets, and the components reflecting the default-mode network (DMN) and dorsal attention network (DAN) identified. Both ICNs showed a high degree of spatio-temporal correlation between BOLD and CBF data at the group and individual level. However, the coupling between metabolism and CBF was substantially higher in the DMN than the DAN, possibly reflecting a difference in the BOLD signal mechanisms in the ICNs.

Keywords

acquisition active activity agreement almost analyses architecture arise astronomy axial background block blocks blood bold bound brain cerebral cognitively coherent comparable components comprising concatenated concurrent conditions conjunction connectivity constant contrast control correlation correlations cortex cortical coupling create crossing dabs deactivations decompose deep default delay despite detailed detect determined disease distension dorsal double effective enable engaging equivalent estimation exclusively explained extracted fair field flirt flow fluctuations frequency functional gave healthy highly identified important independent individual interpolated interrogate intrinsic investigate investigation kingdom label larger literature logging maps maximal measures mechanism median metabolic metabolism methodology modulation motor nature negative nervous network networks occurring overlap partially passive patterns period physics physiological positive previously recent recorded reduce reduced reported response responses responsiveness rest scaled scanner school sense sensory significance simultaneous slices smith smoothed source spatial spontaneous stimulation strength studies subject subjects suggested suggests suppression system task temporal threshold trans underlie understanding valuable variability variables west wrist