Meeting Banner
Abstract #0471

A Turn-Key Solution for the Quantification of Brain Oxygen Metabolism

MAGNA25Peiying Liu1, Feng Xu1, Hanzhang Lu1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

Cerebral metabolic rate of oxygen (CMRO2) is an important index of tissue viability and brain function. Previous MRI measurements of CMRO2 are not yet widely available for clinical applications due to various technical and feasibility reasons. The present study proposed a turn-key solution for quantitative assessment of global CMRO2. While the lack of spatial resolution is the main limitation of the proposed method, it is non-invasive (no exogenous agent), fast (<5 min in scan time), and reliable (Coefficient of variation<3%) and can be performed on a standard clinical scanner. These features afford this technique great potentials for immediate clinical applications.

Keywords

although applications arterial artery assessment available blood brain caffeine cerebral clinical coefficient complete computed conditions consumption contains correlated correlation dataset demonstrating described desirable diseased duration earlier effective emission enhance equation example excellent extraction fast feasibility feasible features feeding find flow fraction global great greater hall healthy highly illustrated immediate important improvements inconsistency incorporated index individual individuals inter interestingly intra invasive lack limitation literature made males many measure measured measures medical metabolic metabolism model models much multiplying niche noise numerous oxygen oxygenation perpendicular person physiologic physiology plot positioning positron potentials precision pressure previously procedure propose proposed proposes pulse quantification quantify reasons recent reduced reflects relatively reliability reliable report reposition repositioning represents reproducibility resolution respectively saturation scanner scatter separate session sessions seven significantly situations solution southwestern spatial studies subject subjects suggesting summarizes susceptibility table technical tends theoretical tissue tomography true trust turn utility variability variation variations various venous vertebral viability widely years young