Quantifying Axonal Injury, Demylination & Inflammation in Human MS Autopsy Specimens Using Diffusion Basis Spectrum Imaging (DBSI)

Keywords

accurately acquisition address anisotropic anti antibodies antibody applied approximation autopsied autopsy axial axon basic basis bath blinded blocked blood blue brain bundles caliber camera capability cell cells close coil column community comparing complications component components computed confounds considered consistent consisting console contained control cord cords correlate cross crossing cylindrically death derived determined developing diameter diffuse diffusion direct dorsal embedded employed equipped estimation examined examining example extremity fibers findings fitting fixed formalin global goat gradient gradients green histology human identified in vivo independently infiltrating infiltration inflammatory injury integrity isotropic lewis linear lymphocytes macrophages magnet maps marked minutes moderate monoclonal mouse nonlinear nonspecific numbness optimization paraffin pathology placed presence preserved press prevent processing profiles quantify quantifying real recorded reduce registered relatively repetition resolve restricted retrieved rinse rise room saint search sections sensitizing served severe severity significantly slice slices sliding software solenoid specimens spectrum spinal squares staining suggesting suggests syringe tend typical vary washing white zero