Meeting Banner
Abstract #0460

Diffusion Enables the Distinction between Types of Tissue Microstructure by Analyzing the Water Lineshape

MAGNA25Alexander Ruh1, Philipp Emerich1, Dmitry S. Novikov2, Valerij G. Kiselev1

1Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany; 2Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, NY, United States

We show analytically and numerically, that the NMR spectral lineshape can distinguish between different kinds of global structural organization (order and various types of disorder) of tissue susceptibility. This distinction involves long-range correlations and is thereby robust to the biological variability. The biophysical mechanism behind this phenomenon is the molecular diffusion mediating the spin dephasing reflected in the transverse relaxation. Our results provide a framework for novel types of susceptibility-based contrast.

Keywords

account achieve agree agreement amount analytically analyze angular appreciated behavior behind better biological biomedical biophysical black blue classes classification conclude consistent constant contrast contribution correlation correlations create cubic dashed diffuse diffusing diffusion directly disorder disordered displaced distance distinct distinction distinguish distribution doped driving effective elements embodies enables energy event exchange explicitly exponents finite force form fraction frequency functions global inclusions independently integration lattice laws length local long macroscopic made manifests maximally media mediating medical medium models molecular much naked narrowing numerical numerically occurs organization overlap packing paramagnetic part periodic permeable perturbation phys physics plateau power probing problem properties qualitatively radiology radius randomly real reflected refs regime regular remain respect revealing robust sample scale school self sensitive shuffled simulation simulations singularity slow space spatial specifically spectral spheres spherical spin spins strength structural susceptibility take terms thereby tissue tissues transform translate transverse treatment treats types utilize variability variance varying volume weak whereas yields