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Abstract #0446

Transverse Relaxation Time (T2) Measurements of the Human Thigh Muscles at High Magnetic Field Using Segmented Echo-Planar Imaging.

Guillaume Duhamel1, Marc Jubeau1, 2, Michal Sdika1, Yann Le Fur1, Sylviane Confort-Gouny1, Christophe Vilmen1, Alexandre Vignaud3, Patrick J. Cozzone1, Julien Gondin1, David Bendahan1

1CRMBM, UMR 6612, CNRS , Aix-Marseille University, Marseille, France; 2Laboratoire "Motricit, Interactions, Performance" - EA 4334, Nantes, France; 3SIEMENS Healthcare, Saint Denis, France

Transverse relaxation time is a relevant parameter used to distinguish activated from non activated muscles as a result of exercise. Widely used CPMG-based sequences suffered from long acquisition time and B1 inhomogeneities sensitivity, especially at high field. We propose a very simple multislice approach based on segmented echo-planar imaging to rapidly and accurately measure muscle T2 values at 3T. The proposed technique was first validated on a phantom study and then applied for in vivo T2 measurements in exercising muscle.

Keywords

accurate accurately achieve acquisition activated activation advantages although analyses applied arising artifacts assessment balance calculating calculation calibrated calibration capabilities carried chosen classic combines compatible conditions considered considering consisted contractions decrease degree despite diagnostic distinguish distorted distortions distribution echoes eight either equation especially evaluated exercise exercising field finally fitting force fully good healthy human immediately in vivo independently inhomogeneities inside interactions isometric largely length limited linear logarithm long magnet mapping maps matrix maximal measure minute minutes mode moderately moreover muscle muscles noticed occurring overall overestimated performance phantom physiologic planar post previous prior processing produced prone proposed providing quadriceps quality quantitative ranging rapidly reaches real recent require required rest saint scale segmentation segmented sensitive seven shortest shot shots significantly simple slice slices slightly sonar spin standardized starts statistically still strategy studies subject subjects system thigh though train transverse true tubes typical usually validated whereas whether widespread