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Abstract #0414

Mapping Magnetic Susceptibility Anisotropies of White Matter in vivo in the Human Brain at 7 Tesla

Xu Li1, 2, Deepti S. Vikram1, 2, Issel Anne L. Lim1, 3, Craig K. Jones1, 2, Jonathan A.D. Farrell1, 2, Peter C.M. van Zijl1, 2

1F.M. Kirby research center for functional brain imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 2Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 3Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States

A method is proposed to map the magnetic susceptibility anisotropy (MSA) and mean magnetic susceptibility (MMS) of brain tissue. This is accomplished by combining GRE phase data collected at a small number of head orientations with fiber direction information obtained from DTI. Simulations were performed to test the reconstruction performance. The reconstructed MMS map in vivo shows good contrast between gray and white matter, while the MSA map reveals most of the major central white matter fiber bundles.

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Keywords

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