Meeting Banner
Abstract #0384

1H Perfusion MRI with the Replacement Effect of D2O

Fu-Nien Wang1, Chin-Tien Lu1, Shin-Lei Peng1, Tzu-Chen Yeh2

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 2Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan

D2O was first proposed as a novel contrast agent for 1H MRI. Previously, D2O was used for perfusion imaging by receiving the deuterium signal. In this study, we alternatively measured the 1H signal reduction due to the replacement effect of deuterium. Because the signal sensitivity of 1H is about 100 times larger than deuterium, the SNR could be substantially increased by using this imaging strategy. Phantom and small animal experiments were conducted to proof the concept. Due to the non-toxicity and non-radioactivity, the D2O could be a potential contrast agent for clinical usage without the need of hardware upgrade.

Abstract PDF Presentation Video

Keywords

acquisition agent aging anesthetized anterior arterial axial barb best beyond blood brain breathing chemical chin clinical coil color comm comparable concentrations contrast cost course dashed decreased deionized deuterium ding directly discussed disorder drop dynamic early empty exogenous fibrosis five freely function general good gradient hand hardware harm hospital improved in vivo indicated inform injected injection inserted inside intensity investigate isotonic isotopes kidney know labeled larger lead limit limited long male maxim measured medical mental mixed molecule molecules national natl negative note owed oxide patients peak perfusion permeability phantom pixel plot plotted popular proposed quality rats realistic regard replaced replacement represent resolution resonant respectively scanned scanner sciences sensitivity shin slice slightly spin studies substitution suffered suppressed susceptibility syringes system tail theoretical theoretically tissue toxicity tracer tube tumor utilize wash water width worthy