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Abstract #0361

Highly Accelerated 3D Spiral Acquisition for Whole Brain Myelin Water Mapping Using a Hybrid SPIRiT-PCA Reconstruction

Thanh D. Nguyen1, Mitchell Cooper1, 2, Pascal Spincemaille1, Bo Xu1, 2, Ashish Raj1, Susan A. Gauthier3, Yi Wang1, 2

1Radiology, Weill Cornell Medical College, New York, NY, United States; 2Biomedical Engineering, Cornell University, Ithaca, NY, United States; 3Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, United States

Recently an SNR efficient 3D T2prep spiral sequence has been developed to provide whole brain coverage in 24 min at 1.5T. We propose to develop a hybrid reconstruction method which combines Iterative Self-consistent Parallel Imaging Reconstruction (SPIRiT) and Principal Component Analysis (PCA) to exploit the spatiotemporal redundancy in multi-component T2 relaxometry to accelerate whole brain coverage from 24 min down to 6.5 min. Comparable myelin water fractions were obtained with the accelerated spiral data at 3T. SPIRiT-PCA may be a promising approach to bringing myelin quantification closer to clinical practice.

Keywords

accelerated acceleration acquisition allow although applied artifacts assessment basis best better biomedical brain bringing calibration called channel clinical closer coil college combination combined component components compromise conjugate consistency consistent constraint constraints convolution corpus coverage curves decay demonstrating density determined develop developed distributions dividing domain effective efficient eight enables energy enforces engineering error errors especially exploiting expressed fidelity fitting formulation fully functions golden gradient head healthy highly human hybrid identity impeded implementation important instr introduced iterative kernel least linear long matching matrix medical minimizing needed negative neurology novel optimal optimized overestimation oversampled parallel pascal performance placed preliminary prep principal problem processing project promising proper propose proposed quantification quantitative radiology random recently reconstructed reconstruction reduce reduction redundancy regularization regularized represents respectively sampled sampling scaled sclerosis self series slice slight solution solves space spatial spiral spirit squares step subject suggest superior synthetic temporal term theory training trajectory trans treatment uniform utility variable water whole