Meeting Banner
Abstract #0355

DTI Using Modulated Gradients at Short Effective Diffusion Times

Henrik Lundell1, Casper Kaae Snderby1, Lise Vejby Sgaard1, Tim Bjrn Dyrby1

1Copenhagen University Hospital Hvidovre, Danish Research Centre for Magnetic Resonance, Hvidovre, Copenhagen, Denmark

Assessment of short term self diffusion processes using oscillating gradient techniques is a topic of recent interest with promising applications in microstructure imaging. In this study we implement a trapezoidal modulated gradient sequence for diffusion tensor imaging and apply it on a perfusion fixed monkey brain sample. We find increased diffusivities in white matter at short effective diffusion times, but overall maintained anisotropy. However, new features emerge at short diffusion times that could be related to microstructures not visible with conventional techniques.

Keywords

allow amplifier anatomically animals anisotropic anisotropy applied arrows attenuation axons better blocks border brain built cell changing clear coil components confirm constant constructed contrast cook corpus cortical cosine decreased described designed diameter diffusion diffusivity dispersion distinct domain earlier effective eigenvalue electrostatic emerged encoding ethical expressed extra extracted feasibility fibers finite fitting fixed flow frequency funds future gore gradient gradients gray green gross half hemisphere home indicating input insight integration interference inverted investigate investigating kept lateral length limiting linear long magnet maintained matrix maximized metrics microscopic modulated monkey moreover mouse numerical optimal oscillating overall parallel parsons pathways periods perpendicular placed post prepared press processes protocol pulse pulsed pulses rapidly readout reconstructed reduced relatively relevant restricted rise rotationally sample scales scanned scanner section selectively sensitivity short slice space spectral spectrum spin stabilized steam steps stimulated strength structures suggests surface temporal tensor term thin tissue train trapezoidal twice varied vector waveform waveforms white whole