Meeting Banner
Abstract #0337

Temporally-Resolved Imaging of Renal Sodium-23 Changes After Furosemid Injection

SUMMA25Raffi Kalayciyan1, Friedrich Wetterling1, Sabine Neudecker2, Norbert Gretz2, Lothar R. Schad1

1Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany; 2Medical Research Center, Heidelberg University, Mannheim, Germany

Since renal function is highly correlated with renal tissue 23Na concentration, 23Na-Kidney-MRI can be used to monitor the spatial changes in 23Na along the corticomedullary axis after diuretics administration. Furthermore, the temporal changes in the medulla and cortex 23Na signals could be studied, if sufficient spatial and temporal resolution can be achieved. The aim of this study was to measure the temporal 23Na signal before and after furosemide-injection in four rats via bilateral renal 23Na-MRI (n=8). In order to maximize 23Na signal at 9.4 T, a 3D-Ultrashort Echo Time (3D-UTE) sequence was used in conjunction with a home-built transceiver surface resonator.

Abstract PDF Presentation Video

Keywords

abdominal abolished according achieved acknowledgment acquisition acute additionally administered administration afterwards application arterial assisted bilateral birdcage bladder blood body bolus built capacitors carried changing characterized circuit clarified clearly clinical coil combination commonly computed concentration conditions conjunction contrast correlated cortex course decrease delineated designed distinct diuresis diuretic diuretics easily enabled every exchange experiment explanation fast filtration financially fitted fixed function furthermore geometrically hence herein highly hour indicated initial injection inner instance investigated investigating ions kidney kidneys linearly literature loop mainly manually maps marked match maximize measured medical medicine medulla monitor need negative nominal normally object offer optimized osmotic outer physiological pixel plots plotted polarized powerful prior projections rare rats reached reduces registered remained renal reported resolution resolved resonator resonators saddle samples scanning sensitivity shaped short since slice slope sodium spatial steady sufficient superior surface table tabulated target temporal temporally tissue took transceiver transplanted tubular tuned urinary urine variable various visualized volumes washed