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Abstract #0299

Myo-Inositol Increase with Age Shows SCN1A Dependency: A 3T MRS Study

MAGNA25Nuran Tunc-Skarka1, Sandra Meier2, Markus Sack1, Wolfgang Weber-Fahr1, Traute Demirakca1, Thomas G. Schulze3, Carsten Diener4, Gabriele Ende1

1Neuroimaging, Central Insitute of Mental Health, Mannheim, Baden-Wrttemberg, Germany; 2Genetic Epidemiology in Psychiatry, Central Insitute of Mental Health, Mannheim, Baden-Wrttemberg, Germany; 3Psychiatry and Psychotherapy, University Medical Center Gttingen, Gttingen; 4Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Baden-Wrttemberg, Germany

Via MRS one of the most frequent findings in white matter of aging brains is a reduced NAA and an increased mI concentration. In our study we wanted to investigate if SCN1A has any effect on the age dependent metabolites in a sample of 49 healthy volunteers. SCN1A is been seen as a novel gene candidate for cognitive decline. We found reduced NAA and Glu and increased Cr and mI with age. Further we found increased mI in the SCN1A risk group.

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Keywords

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