Meeting Banner
Abstract #0281

T2 Mapping & Glycosaminoglycan-Dependent Chemical Exchange Saturation Transfer (GagCEST) Imaging of Focal Lesions in Knee Cartilage Using 3 T MRI

Benjamin Schmitt1, Goetz H. Welsch2, Moritz Zaiss3, Stefan Zbyn, Sabine Goed, Siegfried Trattnig

1Centre for High-Field MR, Medical University of Vienna, Vienna, Austria; 2University Hospital Erlangen; 3German Cancer Research Center (dkfz)

This study presents initial results from gagCEST imaging performed on a clinical 3 T-MR scanner in 3 volunteers and 9 patients with focal knee injuries. In volunteers, the performance of a B0 correction method based on retrospective correction of z-spectra was evaluated by comparison with a standard phase mapping technique. Results from volunteers suggest applicability of the correction method and indicate that gagCEST effects can be measured at 3 T. Patient results show that gagCEST effects are susceptible to changes of T2 values, but could have a value for detection of GAG loss that occurs without affecting T2.

Abstract PDF Presentation Video

Keywords

absolute achieved acquisition actual acute additionally adjacent altered although amplitude apparent applicable approved asked assess assessment asymmetry basis bone cancer cartilage chemical chronic clinical coefficient coil components comprised content continuous corrected correction correlation correlations corresponds course defects degeneration delay delayed dependent detected determined displayed distribution distributions dual duration earliest either elementary employed enhanced exchange exhibit explained feasibility field fits focal frame frequency gadolinium gradient healthy hospital indicated influences inhomogeneities initial injuries institutional intact integrated interpolated invasive investigate knee lesions lifetime linear local loss mapping maps materials matrix measured medical micros morphologic movement necessary offset osteoarthritis participate patients pixel placed position potential properties protons pulse pulses qualitatively quality radiology recently reduced referred registered registration reported represents resolution responsible retrospective review rigid saturation scanner scheme selective sensitivity series significantly smoothing sodium spectra spillover spin spline spoiled stages steam stronger suggest suggested surrounding system systematic tech tissue transfer underestimation variations volume volunteers wave written