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Abstract #0250

DTI of the Inter-Hemispheric Connectivities in Neonates with Transposition of the Great Arteries Undergoing Cardiopulmonary Bypass Surgery.

Malek I. Makki1, Rabia Liamlahi2, Hitendu Dave3, Bea Latal4, Vera Bernet5, Ianina Scheer6, Klaudija Batinic2, Cornelia Hagmann7, Walter Knirsch2

1MRI Research, University Children Hospital Zurich, Zurich, Switzerland; 2Cardiology, University Children Hospital Zurich; 3Congenital Cardiovascular Surgery, University Children Hospital Zurich; 4Child Development, University Children Hospital Zurich; 5Pediatrics Intensive Care, University Children Hospital Zurich; 6Diagnostic Imaging, University Children Hospital Zurich; 7University Hospital Zurich

Fifteen neonates with d-transposition of the great artery underwent DTI before and after cardiopulmonary bypas surgery. The genu and splenium od the corpus callosum were investigated with DTI and compared to ten age amtched healthy neonates. Abnormal white matter growth was reported in the genu but not in the splenium.

Keywords

abnormal abnormalities activation adjacent affected affecting aims anisotropy anterior appear approved around arteries basic birth brain bypass cardiology cardiopulmonary cardiovascular care carried characterization child children color committee completed component conceptional congenital connectivities connectivity consent continues contributed control controls corpus covariance covariate days decrease delayed delineated despite development diagnostic diffusion diffusivity disruption dramatically encoded ethical exam exams extracellular extremities fetal fifteen fractional frontal full furthermore general gestation gradient great grows healthy hemispheric hospital immature indicated influence informed institutional intensive inter intracellular investigate known least likely linear little malinger manually maps marginal matched maturation measure measured measures model modifications neonates observers ongoing organization parallel parents patients pediatrics perpendicular post posterior postnatal procedure process rather recruited reflected regard repeated reported revealed scanner separated separately served sheath significantly simultaneous slices song spaces started statistical structure suggestive surgery surgical term third thought together transposition trimester undergoing underwent water weeks years