The Impact of Overall Injection Time on the Arterial Input Function and Pharmaco-Kinetic Analysis Using the Tofts Model in DCE-MRI for Prostate Cancer Patients

Keywords

according acid acquisition addition agent allows arrow arterial arteries artery body bolus bony boundary cancer carried chosen clear coil concentration constant constants contrast corrected correction cover critical curves decay decreased dependent derived detectable determination determined dispersion drift dynamic enhanced enhancement estimation exam exams exclusion exhibit experimentally exponential extracted feeding femoral fitted fitting form frequency function geometry gradient heads healthy height hence heterogeneity hospital impact impaired included increasing influence injected injection input institute interval intrinsic investigate kinetic known lesion location longer magnitude manual manually material matrix minimal model noise oncology onset optimizing outermost overall overlap parker part partial pass passage patient patients peak peripheral placed preferable prostate protocol protocols proven radiation radiology ranging recirculation reconstruction repeat sampling saturation scanner selected selection series shape sharpening sigmoid simulations since slab slabs slice slices specified speed spoiled straight subtracted suffer suggests theorem tissue transversal transverse tumor turn twice typically unwrapped varying volume width widths zone