Treatment with the MEK Inhibitor U0126 Induces a Decrease in Hyperpolarized Pyruvate to Lactate Conversion in Breast But Not in Prostate Cancer Cells

Keywords

activity administration affect albeit another assays assessed availability beads blotting blue breast cancer cell cells chemotherapy clear clinic clinical complicated concentration conjunction consumption contrast contribute control controls conversion currently decrease delay delivery depletion detectable detection determine determined development discovery drop dropped drug dual effective elevation enhance entering evaluate evaluation even every excitation explanation expression extracted extraction fact final finally findings formation frequently goal good grant greater grown growth highlight hours illustrate illustrates immediately importance importantly improve increasing indeed individual induced inhibition inhibitor inhibitors interactions intracellular investigated known lactate links mechanisms mechanistic mechanistically mediates metabolic metabolism methodology models modulated monitor monitoring moreover namely need novel options outcome particular pathway pathways personalizing potential probed production proliferation prolonged prostate pulse pulses radiation recently reduction remained respectively response sculpting similarly spectra spectrophotometric spite stasis supported suppression system targeted temporal therapies timely transient transport transporter treated treatment trials tumor tumors unchanged understanding unexpected validated western woods