Meeting Banner
Abstract #0167

Mapping in vivo Tumor Oxygenation Within Viable Tumor Using 19F MRI & Multispectral Analysis

Yunzhou Shi1, David Finkle2, Franklin Peale3, Jed Ross1, Maj Hedehus1, Nicholas Van Bruggen1, Suzanna Clark2, Rayna Venook2, Sarajane Ross2, Richard Carano1

1Biomedical Imaging, Genentech Inc.(Roche group), South San Francisco, CA, United States; 2Translational Oncology, Genentech Inc.(Roche group), South San Francisco, CA, United States; 3Pathology, Genentech Inc.(Roche group), South San Francisco, CA, United States

A novel approach that combines 19F MRI oximetry with diffusion-based multispectral analysis was developed. The current study demonstrates that pO2 measurements can be restricted to the viable tumor and that the necrotic tissue classes contribute erroneous data to whole-tumor estimates of the pO2 response during a breathing gas challenge experiment on mice. This novel approach provides a means to measure pO2 within tissue of therapeutic interest and address the issue of tumor heterogeneity that complicates pO2 tumor imaging.

Keywords

ability active addition address adipose agent agents allow animal animals apparent approved biomedical breathing calibration cancer care cells challenge changing class classes clustering coefficient coil combined complicates complications concentrations conditions consistent constructed contain containing contrast contribute coronal cutaneous cyst density described developed development differing diffusion dose employ employed emulsions equilibrium equipped experiment fast features franklin generate green hemorrhage heterogeneity heterogeneous hypoxia in vivo inclusion indicate injected injection inoculated institutional intake intravenous inversion investigations issue issues known leakage like likely mapping maps mask mason matrix meaningful measure measuring mice monitoring mouse nature necrosis necrotic novel nude oncology oxygen oxygenation paired partial pathology physiologically physiology populations potential presence pressure previously prior promise proton quantification quantitatively reach recent recovery regional registered representative respectively response revealed role sample samples segmentation sensitivity sequentially shot south spatial spin statistical strong surface system target technologies therapeutic therapies therapy tissue translational tumor tumors uptake valuable variable vessels viable visualized whole zero