Meeting Banner
Abstract #0162

Imaging the Relationship between Tumour Interstitial Fluid Velocity & Microvascular Perfusion with ConvectionMRI

SUMMA25Simon Walker-Samuel1, Jake Burrell2, Rajiv Ramasawmy1, Peter Johnson3, Jack Wells1, Bernard Siow1, Simon P. Robinson2, Barbara Pedley3, Mark F. Lythgoe1

1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom; 2CR-UK & EPSRC Cancer Imaging Centre, The Institute of Cancer Research, United Kingdom; 3Cancer Institute, University College London, United Kingdom

High tumour interstitial fluid pressure (IFP) is hypothesised to be caused by raised vascular permeability and thus driven by microvascular pressure. We have developed a novel method for measuring tumour interstitial fluid velocity (IFV) named convectionMRI that can map the path of fluid transport through the tumour interstitium. By combining this technique with arterial spin labelling to evaluate vascular perfusion, we have shown a correspondence between IFV spatial distribution, vascular perfusion and spatial pressure gradients that are consistent with this microvascular pressure hypothesis. We discuss the potential for the non-invasive assessment of barriers to drug delivery.

Abstract PDF Presentation Video

Keywords

able adiabatic agents alignment allowed applied aspects barrier belle better biology biomedical bipolar birdcage black blood bulk cancer carcinoma cast casting casts cells coil coincident college combining comprehensive consistent constructed contrasting convection conversely coronal correspond coupled cross days delay delivery dental described developed direct drug edge effective enabled enables encoding evident example examples exhibit fair flowing fluid global gradient gradients green grow highly hinder homogeneously hydrostatic hypothesis illustrated illustrates included injected institute interstitial inversion inverted jack king kingdom laminar locker maps material matrix measured metastasis mice micro models moments named novel null nulling overlaid overlay pathways pattern patterning perfused perfusion permeability post pressure previous probabilistic processing proportional quantifying radial raised rapid readout recovers recovery reduces registered relationship rendered restrained review scale scanned scanner section selected selective slice software source spatial spin streamline streamlines studies therapy thresholding tissues tool towards vascular vectors velocities velocity vessels visage visible volume walker white written yellow