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Abstract #0149

Hybrid Magnetic Resonance & Ultrasound (MR-US) Imaging as a Novel Method of High Intensity Focused Ultrasound Treatment Guidance and Monitoring

MAGNA25Victoria Bull1, John Civale1, Ian Rivens1, David J. Collins2, Gail ter Haar1, Martin O. Leach2

1Department of Radiotherapy and Imaging, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; 2CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

Although MRI is considered the gold standard for HIFU treatment guidance, it lacks the ability to interrogate blood flow and monitor cavitation during treatments. A hybrid MR-ultrasound (MR-US) imaging system has shown promise as an improved technique, allowing real-time Doppler ultrasound and B-mode cavitation detection to be performed simultaneously with MR thermometry. A comparative study of truly simultaneous MR-US thermometry has also been conducted, showing good correlation between measurements of temperature change. The appearance of cavitation correlated with fluctuations in MR thermometry, and colour Doppler added dynamic information to MR angiographs. This system is a strong candidate for clinical use.

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