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Abstract #0133

Resing State FMRI Slow Fluctuations Correlate with the Activity of Fast Cortico-Cortical Physiological Connections

Giacomo Koch1, 2, Marco Bozzali3, Sonia Bonni1, Viola Giacobbe1, Carlo Caltagirone1, 2, Mara Cercignani, 34

1Laboratory of Clinical and Behavioural Neurology, Santa Lucia Foundation, Rome, Italy; 2Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy; 3Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; 4CISC, Brighton and Sussex Medical School, Brighton, United Kingdom

Multifocal TMS allows the investigation of the causal neurophysiological interactions occurring in specific cortico-cortical connections, and the aim of this work is assessing the correlation between measures of brain connectivity obtained with TMS and resting state fMRI. Results showed that the activity of fast cortico-cortical physiological interactions occurring in the millisecond range correlated selectively with the coupling of fMRI slow oscillations within the same cortical areas that form part of the dorsal attention network. We conclude that resting-state fMRI slow fluctuations are likely to reflect the interaction of underlying physiological cortico-cortical connections

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Keywords

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