Meeting Banner
Abstract #0131

Individualized Mapping of the Subgenual Cingulate in Individual Unipolar Depressed Patients Using fMRI

Leslie Baxter1, Gary Grove2, Ryan Smith1, Perri Handley1, Michael Purcell1, Francisco Ponce3, Robert Spetzler3

1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States; 2Private Practice, Scottsdale, AZ, United States; 3Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, United States

Deep Brain Stimulation is a new intervention for treating severe depression; however, response rates may be improved with fMRI if the region in the dysfunctional subgenual cingulate is better targeted. We developed a novel fMRI sadness induction paradigm that collects standardized blocks of data within a flexible-block design. Specifically, when subjects attain the targeted emotional state (sad or neutral), they trigger a standardized 30 block through a button press. Only those blocks are analyzed in the post-processing steps. Our preliminary data show that depressed patients can perform this task and generally show greater subgenual responsivity compared to controls.

Abstract PDF Presentation Video

Keywords

ability account achieve activation adjusting almost altered among analyses analyzed anatomy attaining barrow beck behavior block blocks brain capitalizes clinical coil condition conditions considered consistent control controls corner cortex covering currently deep define defined depressed depression design designed developed development diagnosis disorder disorders distinguishing eloquent engaging examine extent flexible frontal functional functionality functionally general generally goal good gradient greater grove handed head highlighting hypothesized improving indicating individual individualized individuals induction institute interview investigate least length lobe location longer maintain maintaining major mapping maps mask minimal moderate native neurological neurosurgery neutral novel offer paradigm participants patient patients phoenix planar ponce poor post potentially practice previously prior private processing recently recognized regard related relatively resistant resolution respond returned robust sadness scanning scores severe smith smoothing space spatial standardized statistical steps stimulation stimuli structural studies subjects system targeted targeting task therapies threshold tolerated took transition treatment ultimately unipolar upper variable variations versus widely years