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Abstract #0128

Altered Frontostriatal Cortical Functional Connectivity in Heroin-Dependent Individuals: A Resting-State FMRI Study

Yarong Wang1, Jia Zhu2, Qiang Li2, Wei Li2, Ning Wu2, Haifeng Chang2, Ying Zheng2, Wei Wang2

1Department of Radiology, Tangdu Hospital,The Fourth Military Medical University, Xi'an, Shaanxi , China; 2Department of Radiology, Tangdu Hospital,The Fourth Military Medical University, Xi'an, Shaanxi, China

Though MRI studies have associated heroin use with a large scale structural and functional brain abnormalities, few fMRI studies focused on the balance between local neuronal activity and global integrative processes during a resting-state in heroin-dependent individuals (HD). Measurement of amplitude of low frequency fluctuation (ALFF) can successfully characterize the nature and extent of signal change underlying spontaneous neuronal activities in HD. This paper strongly emphasizes the association between the heroin-use-induced ALFF alteration and the resting-state functional connectivity of these brain regions, and reveals a heroin-use-related dysfunction of frontostriatal cortical system, the substrate of an impaired inhibitory control in HD.

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Keywords

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