Meeting Banner
Abstract #0125

Activation & Deactivation in the Cerebellum in Schizophrenia Studied Using Verbal Working Memory FMRI

Kayako Matsuo1, S.H. Annabel Chen2, Chih-Min Liu3, Chen-Chung Liu3, Hai-Go Hwu3, Wen-Yih I. Tseng1

1National Taiwan University College of Medicine, Taipei, Taiwan; 2Division of Psychology, Nanyang Technological University, Singapore; 3Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan

We applied verbal working memory (VWM) fMRI to investigate schizophrenia specifically focusing on the cerebellum. We designed high and low load conditions to examine two contrasts: high > low load contrast for the VWM activation, and low > high load contrast for the default mode network (DMN) “deactivation”. The VWM contrast activation overlapped with the Cerebellum VI, Crus I and Vermis. In contrast, the DMN contrast yielded activation in the Crus II of the cerebellum. An extensive “deactivation” observed in the control group but not in the schizophrenia group might be an indicator of the disease.

Keywords

accuracy activation affect alternation anatomy angular applied array automated better binary blue cerebellar cerebellum circuit cognition cognitive coil computed conditions confounding conjunction consent consistent consonant cont contrast contrasts control controls coordinates core cortex covariates created cross deactivation default delay designed detailed directed disease distinctiveness division education either employed ensure epochs extensive failure focusing former fully functional functions gender global handedness healthy honey important indicate indicated indicates indicating internally investigate involved larger lateral latter letter letters load loads local lowercase magenta mask masks materials matrix maximize medial memory might minimize minutes mode national network overall overlap overlapped parietal partly patients phonological plays positive posterior pressing probe psychiatry random response retrieval role sample scanner schizo schizophrenia score segregations sessions significantly sixteen slice slices specifically statistics stimuli storage structures studied subject subjects suggested summation symptoms table technological template though transformation trio uncorrected understood uppercase verbal view views volumes volunteered wide world written yield yielded