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Abstract #0094

Interaction of Cortex & White Matter During Development Accessed by Cortical Thickness & Microstructure of Projected Axons

Tina Jeon1, Virendra Mishra1, Yong He2, Hao Huang1, 3

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; 3Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States

Cellular activities occurring in the cortex during development can drive the structural changes of not only cortex but also white matter. The interaction between cortex and white matter may be accessed with microstructural measurements of white matter traced from this cortical region. In this paper, , we parcellated the cortex into 66 gyri and measured the fractional anisotropy (FA) of white matter tracts projected from the local cortex with a certain gyral label with DTI tractography from data of 26 normal children. Significant negative correlations of thickness and FA of traced white matter were found in most of frontal gyri.

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Keywords

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