Meeting Banner
Abstract #0071

A Kinetic Model for Vessel-Encoded Dynamic Angiography with Arterial Spin Labeling

MAGNA25Thomas W. Okell1, Michael A. Chappell, 12, Ursula G. Schulz3, Peter Jezzard1

1FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, United Kingdom; 2Institute of Biomedical Engineering, Department of Engineering, University of Oxford, Oxford, Oxfordshire, United Kingdom; 3Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, United Kingdom

Vessel-encoded dynamic angiography with arterial spin labeling is able to produce artery-specific images qualitatively showing the blood flow patterns, vessel morphology and hemodynamics. Here we develop a kinetic model to describe the signal in such acquisitions, allowing the generation of parameter maps relating to blood volume, arrival time and dispersion, which may provide useful biomarkers of disease. These parameters are also used to generate intuitive inflow images and calculate the relative blood volume flow rates in downstream vessels from each feeding artery. Results from application of these methods in healthy volunteers and a patient with Moyamoya disease are shown.

Abstract PDF Presentation Video

Keywords

accounting accurately achieved almost angiography applicable approximation arrival arrows arterial arteries artery assessment association attenuated attenuation biomedical blood blue bolus brain calculations carotid cerebral clinical clinicians coded collateral color commences continuous contribution convolution coronal decay delayed depends described digital disease diseased diseases dispersion distal downstream dynamic earliest engineering equal ethics evident example excitation exclusively expected experienced extensive feeding fits fitted fitting flow formation function gamma give gives greater green healthy highlighted ideal importance inflow internal interpretation intuitive invasive kinetic kingdom labeled labeling larger local magenta maintain maps middle model outflow oxford patient patterns peak peter post posterior prevention previous produced profile proportional protocols proximal pulse pulses purple rather recruited relates remaining repetition represent respectively risks scaling scanned scanner selective sharpness source spin stroke subtraction suggesting summing supply support synthesized theory therapeutic tissues together train transit transverse trust unlike variate vertebral vessel vessels views visualization visualized vital volume volunteer volunteers white written