Comparison of Hyperpolarized [1-13C] Dehydroascorbate-MR and FDG-PET in a Transgenic Prostate Cancer Model

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accumulation advantage agents aggressiveness alterations anesthetized antigen appeared benign biomedical bladder brain cancer capacity care cells cellular charge clinical cohort coil color concentrations contamination continuous conversion correlating coupled cover custom described determine developed differentiated difficult difficulty dimer dissolution dissolved drawn dual early elevated elucidate enzymes essentially fairly fasted finding frame future glucose glut goal gold grant harbor hardware highly human hypothesis hypoxia identical in vivo injected injection intracellular isotropic known limitations local manufacturer matrices matrix mediated metabolic metabolism metastatic mice minutes model models monitor mouse needed nuclear operating outcomes overlap overlay oxidation package pathologic patients perfusion place plays poorly positive positron post previously primarily probe processed projections proliferation proliferative prostate quantify radiology rapidly reactions recent reconstructed reduced reducing reduction regional relates represent representative response responsible scanner several significantly since software sponsors structure studies surrounding takes tend therapy tissue tissues tomography tramp translation transport treatment trial tube tumor tumors tuned unpublished uptake vitamin written