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Abstract #0043

Transcatheter Intraarterial Perfusion MRI Is an Intra-Procedural Imaging Biomarker to Predict Survival During Chemoembolization of Hepatocellular Carcinoma

Dingxin Wang1, 2, Ron Gaba3, Brian Jin4, Robert Lewandowski4, 5, Robert Ryu4, Kent Sato4, Laura Kulik6, Mary Mulcahy7, 8, Andrew Larson4, 5, Riad Salem4, 5, Reed Omary4, 5

1Siemens Medical Solutions USA, Inc., Minneapolis, MN, United States; 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 3Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States; 4Department of Radiology, Northwestern University, Chicago, IL, United States; 5Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, United States; 6Department of Hepatology, Northwestern University, Chicago, IL, United States; 7Department of Medicine, Northwestern University, Chicago, IL, United States; 8Robert H. Lurie Comprehensive Cancer Center,, Northwestern University, Chicago, IL, United States

In this study, we tested the hypothesis that TRIP-MRI monitored tumor perfusion changes during TACE can predict overall survival in patients with unresectable HCC. Our study shows the evidence of association between intra-procedural tumor perfusion reduction during TACE and overall survival. TACE provided better survival benefit when relative perfusion reduction was 35-85%. The present results also suggest that TRIP-MRI performed within an integrated MR-DSA unit may serve as an intra-procedural imaging biomarker to predict survival in patients with unresectable HCC at the time of TACE procedure.

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