Meeting Banner
Abstract #0031

Striatum-Motor Network Functional Connectivity Deficits in Amyotrophic Lateral Sclerosis:A Resting State fMRI

Ming Zhang1, Pan Lin2, Chenwang Jin1, Cuiping Mao1, Chen Niu1, ZhiGang Min1, Jingxia Dang3, Qiaoting Jin3, Xin Liu2

1Department of Medical Imaging, the First Affiliated Hospital of Medical College,Xian Jiaotong University, Xi'an, Shaanxi, China; 2Key Laboratory of Biomedical Information Engineering of Education Ministry, Xian Jiaotong University, Xi'an, Shaanxi, China; 3Department of Neurology, the First Affiliated Hospital of Medical College,Xian Jiaotong University, Xi'an, Shaanxi, China

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease characterized by deficits in motor systems.Striatum-motor network has found to play important role in motor control.Whether the fluctuations of resting fMRI signal within striatum-motor network funtional connectivity is associated with abnormal neuronal activity remains unclear.In this study, we specifically investigate wheather patients with ALS is associated with dysfunction of interregion functional connectivity in striatum-motor network that support motor function.

Abstract PDF Presentation Video

Keywords

abnormal acknowledgments acquisition activity affiliated alteration anything asked averaging band bilateral biomedical bold brain central cerebral channel characterized china closed coefficient coefficients college computing connectivity consisted control controls converted correction correlation cortex course covariates create cross dang decrease deficits define disease dysfunction education eight eliminated engineering equipped error evaluate extracting eyes family filtering fisher fluctuations foundation function functional fundamental funds global head healthy hospital important indicated inter interregional investigated laboratory lateral linear loss major matched matrix medical ming ministry motion motor national natural network neurology neuronal neurons normalization nuisance pairwise participant participated particular pass patients people peoples play possibility press processing progressive receive reflects regression relatively remains reorganization republic resting role sample scanner science sclerosis scores seed seeds series seven several significantly slice slices smoothing software sources space spatial specifically strength structural subject subjects support supported system systems taken template temporal think threshold transformation unclear universities upper whether white whole wise